Making his debut on October 2012 aged 18 Lowe has a so far unbeaten record standing at 9 wins. Between October 2012 and November 2014, Lowe had his longest winning streak of 9 fights. In his 9 fights, his longest KO streak is 2 fights long.
In a memorable debut Lowe gained a TKO win against Michael Stupart in a 4 round contest, becoming the 4th person to stop Stupart. Following his debut, Lowe had an impressive start to his career as he went on to win his next 5 fights including 2 times in 2012 and 3 times in 2013 fighting the likes of as Aaron Flinn, Michael Stupart and Harvey Hemsley.
On December 14th, 2012 Lowe fought and beat Harvey Hemsley (1-2-0) to continue his unbeaten streak. Continuing his career, Lowe fought Harvey Hemsley in 2012 over 4 rounds. Lowe was the 3rd person to go the distance with Harvey Hemsley.
Next was Delroy Spencer on April 20th, 2013 where Lowe took the win continuing his unbeaten streak. Spencer was stopped in the 2nd round via KO meaning Lowe was the 15th person to stop this opponent. Lowe's win streak of 3 rose to 7 following 4 great wins, becoming the first to stop Aaron Flinn, 64th person to beat Pavels Senkovs and 162nd person to defeat Kristian Laight.
On May 17th, 2014 Lowe fought and beat Andy Harris (3-12-1) to continue his unbeaten streak. Lowe secured the win over Harris after the final bell via PTS, resulting in Lowe being the 13th person to defeat Harris.
Isaac Lowe went into his latest fight with Simas Volosinas on November 22nd, 2014 with 8 wins and he continued this winning streak taking it to 9 wins. Lowe out-boxed Volosinas over 4 rounds in his most recent performance, taking the win via PTS and moving on to bigger and better things.