Before finishing his career in March 1978 orthodox boxer Mazzinghi built up a record of 64 wins, 0 draws, and 3 losses, starting at age 22 on September 1961 and ending 16 years later at . The longest KO streak that Mazzinghi has ever had is 7 throughout his 69 fights and his longest winning streak is 24 wins. This started on September 1961 and came to an end on April 1965.
Mazzinghi didn't take long to get comfortable in the pro game, becoming the first person to stop Severino Gagliardi (a 0 fight pro) via KO in the 2nd round. Continuing on from his debut, Mazzinghi had an impressive start to his career as he went on to fight 34 fights including 5 times in 1961, 17 times in 1962 and 12 times through 1963 and 1964 against fighters such as Rocky Randell, Ralph Dupas and Ralph Dupas.
On July 27th, 1962, Mazzinghi took on and was defeated by Giampaolo Melis in his first career defeat meaning his career tally went to 16-1-0. Coming into the fight with high confidence Mazzinghi fought his next fight against Giampaolo Melis on July 27th, 1962. Unfortunately, Mazzinghi was outclassed and lost the decision on the judges scorecards taking his record to 16-1-0. Fights against Francesco Fiori, Rocky Randell, Hippolyte Annex and 9 others followed where he won all 12 fights taking his winning streak to 28 wins.
Mazzinghi kept his losses at 1 by beating Ralph Dupas on September 7th, 1963. The win against Dupas came in the 9th round of a 15 round fight via TKO. Mazzinghi was the 3rd person to stop Dupas. Mazzinghi then went on to win a further 6 fights taking his record to 35 wins, 1 losses and 0 draws.
On November 6th, 1964, Mazzinghi went into action again and beat Gaspar Ortega taking the winning record to 36 wins. The win against Ortega happened in the 7th round of a 10 round fight via TKO. 4 wins followed for Mazzinghi including being the 5th person to stop Isaac Logart, 4th person to stop Mel Ferguson (Round 3 KO) and 7th person to defeat Fortunato Manca.
Mazzinghi went into his next fight against Nino Benvenuti on June 18th, 1965 with a career record of 40-2-0. Mazzinghi was beaten by Nino Benvenuti in the 6th round. The win came via KO in the 6th round. This was Mazzinghi's first stoppage defeat. Mazzinghi then went on to win a further 23 fights taking his record to 60 wins, 3 losses and 0 draw.
Pushing his career further, Mazzinghi fought Willie Warren on October 31st, 1970 adding to his winning record. Warren was stopped in the 8th round via KO meaning Mazzinghi was the 2nd person to stop this opponent.
Sandro Mazzinghi went into his fight with Jean-claude Warusfel on March 4th, 1978 with 63 wins and he added another win to his record taking it to 64 wins by beating Warusfel. Still causing trouble for his opponents, Mazzinghi became only the 10th person to defeat Warusfel in a tough fight over the full 10 rounds. After 69 fights, this was Mazzinghi's final fight as a pro.