Before finishing his career in January 1940 orthodox boxer Manfredo built up a record of 74 wins, 8 draws, and 24 losses, starting at age 17 on July 1930 and ending 9 years later at . Manfredo's longest KO streak is 4 fights long out of his 106 career fights.
Getting rid of his debut fight nerves early, Manfredo took on Johnny Dennis in July 1930 and claimed a stoppage victory (round 4, TKO). Manfredo was the first person to have ever stopped Dennis. Continuing on from his debut, Manfredo had an impressive start to his career as he went on to fight 56 fights including 10 times in 1930, 14 times in 1931 and 27 times through 1932, 1933 and 1934 against fighters such as Baby sal Sorio, Mike Payan and Sammy Mandell.
Manfredo lost to Guy Mckenna in his next fight. Taking place on November 20th, 1931, Manfredo's career record after this fight stood at 24-1-1. Manfredo's first defeat came over the full distance against Guy Mckenna on November 20th, 1931. The fight went to the judges in a PTS loss for Manfredo. Fights against boxers including Lloyd Smith, Don La rue and Lloyd Smith followed where he won 14 fights taking his winning streak to 37 wins.
Glen Musselman was the next fight for Manfredo on February 22nd, 1933 and also his next career win. Manfredo was the first person to stop Glen Musselman and he did it in the 3rd round via TKO. Manfredo's win streak of 38 rose to 47 following 9 great wins, becoming the 2nd person to go the distance with Billy Yalotz, 8th person to stop Johnny Freeman (Round 2 KO) and 13th person to defeat Charlie Hernandez.
Manfredo entered his next fight with a mostly successful record of 47-1-2 and took this to 48 wins with a win against Sammy Mandell on March 13th, 1934 via KO. Becoming the 5th fighter to stop Mandell in his career, Manfredo beat Mandell via KO in the 4th round of a 10 round fight.
Manfredo lost to Eddie Frisco in his next fight. Taking place on March 25th, 1936, Manfredo's career record after this fight stood at 58-8-5. Eddie Frisco became the first person to stop Manfredo. The win came via TKO in the 5th round of a 10 round bout.
On May 22nd, 1939, Manfredo went into action again and beat Johnny Stevens taking the winning record to 71 wins. Stevens was a great challenge for Manfredo, losing over the full 10 round distance and crowning Manfredo as the 11th person to have defeated Stevens.
Taking another knock in his career, Manfredo fought Freddie Dixon on January 15th, 1940 and was defeated by Dixon. Showing he is not at the level he once was, Manfredo took a decision loss to end his 106 fight career. The fight ended in a PTS loss for Manfredo.